Victorian child volunteers wanted for a trial of a nasal spray to avoid tonsillectomy

The MIST Trial at the Murdoch Children’s Research Institute

What is MIST?

Snoring and difficulty breathing while asleep is very common in childhood and can cause lots of sleepless nights, as well as behaviour and concentration problems during the day. An anti-inflammatory nasal spray is being trialled by researchers on small children with breathing and sleeping difficulties Up to now, the main treatment for snoring and difficulty breathing in sleep is surgery. Researchers want to see if a nose spray (mometasone) can help children sleep better and avoid surgery.  This medicine is already commonly used in children with hay fever and is available over the counter (without a prescription).

Some children will be given a placebo as the trial is being conducted as a double blind randomised controlled trial – that is one where neither the researchers or parents know if the child is given the active spray or a placebo. Researchers want to enlist 300 children.

Who can take part?

Families with children:

  • aged 3-12 years
  • who snore most nights and have some difficulty during sleep

Who can’t take part?

Children who:

  • have already had their tonsils removed
  • have a serious long-term health problem

What will I be asked to do?

  • Attend 2 visits at either Monash Health or the Royal Children’s hospital, 6 weeks apart
  • Give your child nose spray of the active medicine or placebo (saline) every day, for 6 weeks
  • Complete 4 short surveys over the next 2 years.

If you are interested in being a part of the voluntary trial you can register online.